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KMID : 0354719920160020120
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Journal of Korean Diabetes Association
1992 Volume.16 No. 2 p.120 ~ p.127
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The Frequencies of HLA DQA1, DQB1 Alleles in Korean Adult Onset IDDN
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홍성관
안종호/고경수/박경수/김성연/조보연/이홍규/고창순/민헌기
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Abstract
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Background:
@EN The incidence of IDDM in Oriental including Korean is 1/10~1/20 of the Caucacian. Recently. some investigators explain the racial difference iorcilnical characteristics and incidence with the difference of the susceptibility genes and/or with
their
frequency in the general population of that race.
@ES Methods:
@EN To identify the susceptibility genes in the development of IDDM among Korean adults, the genotyping of HLA DQA1, DQB1 alleles was performed for 28 adult IDDM patients, and 38 normal controls using the sequence specific oligonucleotide probes.
@ES Results:
@EN The frequency of HLA DQA1 *0301 allele is increased in the Korean adult IDDM patients comparing with normal controls, but the frequency of HLA DQB1 *0302, 0201 alleles, which are well-known susceptibility genes in the development of IDDM in
Caucacian subjects were not increased.
@ES Conclusion:
@EN These results suggest that one of the sesceptibility genes in the development of of IDDM. Among Korean adults is HLA DQA1 *0301 allele.
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KEYWORD
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